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Paratrimerin I, cytotoxic acridone alkaloid from the roots of Paramignya trimera
Natural Product Research ( IF 1.9 ) Pub Date : 2020-06-04 , DOI: 10.1080/14786419.2020.1774760
Mai Thanh Thi Nguyen 1, 2, 3 , Phu Hoang Dang 1, 3 , Hai Xuan Nguyen 1, 3 , Tho Huu Le 1, 3 , Truong Nhat Van Do 1, 3 , Phuc Van Pham 3, 4 , Sinh Truong Nguyen 3, 4 , Nhan Trung Nguyen 1, 2, 3
Affiliation  

Abstract

Bioactivity-guided fractionation of the CHCl3-soluble extract of the roots of Paramignya trimera was carried out to obtain a new acridone alkaloid, paratrimerin I. Its structure was elucidated based on NMR spectroscopic data interpretation. Paratrimerin I showed noteworthy cytotoxicity against the HepG2 human hepatocellular and MCF-7 human breast carcinoma cell lines, with the submicromolar IC50 values of 0.43 and 0.26 µM, respectively. The N-methyl, C-4 methoxy, and C-5 hydroxy groups in the acridone skeleton can be proposed as a structural feature for good cytotoxicity.



中文翻译:

Paratrimerin I,来自 Paramignya trimera 根的细胞毒性吖啶酮生物碱

摘要

聚体根的 CHCl 3可溶性提取物进行生物活性引导分馏,以获得新的吖啶酮生物碱,副三聚体 I。基于 NMR 光谱数据解释阐明了其结构。Paratrimerin我展示针对HepG2人肝癌和MCF-7人乳腺癌细胞系的细胞毒性显着的,具有亚微摩尔的IC 50为0.43和0.26的值 μ男,分别。吖啶酮骨架中的N-甲基、C-4 甲氧基和 C-5 羟基可被认为是具有良好细胞毒性的结构特征。

更新日期:2020-06-04
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