Abstract

Bioactivity-guided fractionation of the CHCl₃-soluble extract of the roots of Paramignya trimera was carried out to obtain a new acridone alkaloid, paratrimerin I. Its structure was elucidated based on NMR spectroscopic data interpretation. Paratrimerin I showed noteworthy cytotoxicity against the HepG2 human hepatocellular and MCF-7 human breast carcinoma cell lines, with the submicromolar IC₅₀ values of 0.43 and 0.26 µM, respectively. The N-methyl, C-4 methoxy, and C-5 hydroxy groups in the acridone skeleton can be proposed as a structural feature for good cytotoxicity.

中文翻译：

---

Paratrimerin I，来自 Paramignya trimera 根的细胞毒性吖啶酮生物碱

摘要

对_三聚体根的 CHCl ₃可溶性提取物进行生物活性引导分馏，以获得新的吖啶酮生物碱，副三聚体 I。基于 NMR 光谱数据解释阐明了其结构。Paratrimerin我展示针对HepG2人肝癌和MCF-7人乳腺癌细胞系的细胞毒性显着的，具有亚微摩尔的IC ₅₀为0.43和0.26的值 μ男，分别。吖啶酮骨架中的N-甲基、C-4 甲氧基和 C-5 羟基可被认为是具有良好细胞毒性的结构特征。