ABSTRACT

This review utilizes the robust database of literature contained in toxicological profiles developed by the Agency for Toxic Substances and Disease Registry. The aim was to use this database to identify developmental toxicity studies reporting alterations in hormone levels in the developing fetus and offspring and identify windows of sensitivity. We identified 74 oral exposure studies in rats that provided relevant information on 30 chemicals from 21 profiles. Most studies located provided information on thyroid hormones, with fewer studies on anterior pituitary, adrenal medulla, ovaries, and testes. No studies pertaining to hormones of the posterior pituitary, pancreas, or adrenal cortex were located. The results demonstrate that development of the endocrine system may be affected by exposure to environmental contaminants at many different points, including gestational and/or lactational exposure. Moreover, this review demonstrates the need for more developmental toxicity studies focused on the endocrine system and specifically alterations in hormone levels.

 抽象的

本综述利用了有毒物质和疾病登记局开发的毒理学概况中包含的强大文献数据库。目的是利用该数据库来识别发育毒性研究，报告发育中胎儿和后代激素水平的变化，并确定敏感性窗口。我们确定了 74 项大鼠经口暴露研究，提供了 21 份资料中 30 种化学物质的相关信息。大多数研究提供了有关甲状腺激素的信息，而有关垂体前叶、肾上腺髓质、卵巢和睾丸的研究较少。没有找到有关垂体后叶、胰腺或肾上腺皮质激素的研究。结果表明，内分泌系统的发育可能会受到许多不同时间点环境污染物暴露的影响，包括妊娠期和/或哺乳期暴露。此外，本综述表明需要进行更多的发育毒性研究，重点关注内分泌系统，特别是激素水平的改变。