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Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19
The Journal of Immunology ( IF 4.4 ) Pub Date : 2020-06-03 , DOI: 10.4049/jimmunol.2000513
Jeremy K Y Yap 1 , Miyu Moriyama 2 , Akiko Iwasaki 3, 4, 5
Affiliation  

The inflammatory response to severe acute respiratory syndrome–related coronavirus 2 infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients. Of the many innate immune pathways that are engaged by severe acute respiratory syndrome–related coronavirus 2, we highlight the importance of the inflammasome pathway. We discuss available pharmaceutical agents that target a critical component of inflammasome activation, signaling leading to cellular pyroptosis, and the downstream cytokines as a promising target for the treatment of severe coronavirus disease 2019–associated diseases.

中文翻译:

炎症小体和焦亡作为 COVID-19 的治疗靶点

严重急性呼吸综合征相关冠状病毒2感染的炎症反应对2019冠状病毒病患者的临床结果有直接影响。在与严重急性呼吸综合征相关的冠状病毒2相关的许多先天免疫途径中,我们强调了炎性体途径的重要性。我们讨论了针对炎症小体激活关键成分、导致细胞焦亡的信号传导以及下游细胞因子的可用药物,作为治疗 2019 年冠状病毒病相关严重疾病的有前景的靶点。
更新日期:2020-06-03
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