Receptor‐like kinases MDS1 and MDS2 promote SUMM2‐mediated immunity,Journal of Integrative Plant Biology

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Receptor‐like kinases MDS1 and MDS2 promote SUMM2‐mediated immunity
Journal of Integrative Plant Biology ( IF 9.3 ) Pub Date : 2020-06-04 , DOI: 10.1111/jipb.12978
Yanan Liu _{1,

2} , Xionghui Zhong ₂ , Zhibin Zhang ₂ , Jiameng Lan ₂ , Xingchuan Huang _{1,

2} , Hainan Tian ₃ , Xin Li ₂ , Yuelin Zhang ₂

Affiliation

Disruption of the MEKK1‐MKK1/MKK2‐MPK4 kinase cascade leads to activation of immunity mediated by the nucleotide‐binding leucine‐rich repeat (NLR) immune receptor SUMM2, which monitors the phosphorylation status of CRCK3. Here we report that two receptor‐like kinases (RLKs), MDS1, and MDS2, function redundantly to promote SUMM2‐mediated immunity. Activation of SUMM2‐mediated immunity is dependent on MDS1, and to a less extent on MDS2. MDS1 associates with CRCK3 in planta and can phosphorylate CRCK3 in vitro, suggesting that it may target CRCK3 to positively regulate SUMM2‐mediated signaling. Our finding highlights a new defense mechanism where RLKs promote NLR‐mediated immunity.

中文翻译：

受体样激酶 MDS1 和 MDS2 促进 SUMM2 介导的免疫

MEKK1-MKK1/MKK2-MPK4 激酶级联反应的中断导致由核苷酸结合的富含亮氨酸重复序列 (NLR) 免疫受体 SUMM2 介导的免疫激活，该受体监测 CRCK3 的磷酸化状态。在这里，我们报告了两种受体样激酶 (RLK)，MDS1 和 MDS2，具有冗余功能以促进 SUMM2 介导的免疫。SUMM2 介导的免疫激活依赖于 MDS1，在较小程度上依赖于 MDS2。MDS1 与植物中的CRCK3 结合并可以在体外磷酸化 CRCK3 ，表明它可能靶向 CRCK3 以正调节 SUMM2 介导的信号传导。我们的发现突出了一种新的防御机制，其中 RLK 促进 NLR 介导的免疫。

更新日期：2020-06-04

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