Affected by environmental factors such as oxygen deficiency, the secretion of growth factor was abnormal in bone injury sites, resulting in the poor responses of osteoblasts and prolonging the healing process. Herein, in this study, we reported an in situ oxygen‐releasing porous titanium coating that combines the dual degradability of poly(lactic‐co‐glycolic acid) with the self‐releasing oxygen capacity of the CaO₂ core. The resulting formulation exhibited stable oxygen‐releasing capacity as well as the ability to promote proliferation and differentiation of the MC3T3 cell line under hypoxia conditions. According to these results, oxygen‐releasing coatings based on improved cellular microenvironment may be a promising bone repair material that would reduce the incidence of difficult bone healing in the future.

中文翻译：

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用于改善缺氧环境中细胞反应的新型释氧涂层的制备和特性。

受缺氧等环境因素的影响，骨损伤部位生长因子的分泌异常，导致成骨细胞反应不良，延长愈合过程。在此，在本研究中，我们报道了一种原位释氧多孔钛涂层，它结合了聚（乳酸-乙醇酸共聚物）的双重降解性和 CaO ₂核的自释氧能力。所得制剂表现出稳定的释氧能力以及在缺氧条件下促进 MC3T3 细胞系增殖和分化的能力。根据这些结果，基于改善的细胞微环境的释氧涂层可能是一种很有前途的骨修复材料，可以降低未来骨难愈合的发生率。