Understanding the mechanisms that regulate hair cell (HC) differentiation in the organ of Corti (OC) is essential to designing genetic therapies for hearing loss due to HC loss or damage. We have previously identified Fibroblast Growth Factor 20 (FGF20) as having a key role in HC and supporting cell differentiation in the mouse OC. To investigate the genetic landscape regulated by FGF20 signaling in OC progenitors, we employ Translating Ribosome Affinity Purification combined with Next Generation RNA Sequencing (TRAPseq) in the Fgf20 lineage.

中文翻译：

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通过翻译核糖体亲和纯化分析 Corti 祖细胞器官中 FGF20 调节的基因。

了解调节 Corti (OC) 器官中毛细胞 (HC) 分化的机制对于设计针对因 HC 损失或损伤导致的听力损失的基因疗法至关重要。我们之前已经确定成纤维细胞生长因子 20 (FGF20) 在 HC 中具有关键作用并支持小鼠 OC 中的细胞分化。为了研究 OC 祖细胞中 FGF20 信号调控的遗传景观，我们在Fgf20谱系中采用了翻译核糖体亲和纯化结合下一代 RNA 测序 (TRAPseq) 。