Chemical Knockdown of MicroRNA with Small-Molecule Chimeras.,ChemBioChem

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Chemical Knockdown of MicroRNA with Small-Molecule Chimeras.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-06-04 , DOI: 10.1002/cbic.202000287
Yi Feng ₁ , Jinbo Li ₁ , Yan Zhang ₁

Affiliation

Targeting “undruggable” RNA: In this concept article, we introduce the development and application of small‐molecule chimeras (SMCs) to the targeted degradation of microRNAs. Due to their high specificity and potency, SMCs present an unprecedented chemical approach to knock down endogenous miRNAs, and thus should contribute to both biological discovery and therapeutic development.

中文翻译：

MicroRNA与小分子嵌合体的化学敲低。

针对“无药害” RNA：在本概念文章中，我们介绍了小分子嵌合体（SMC）在针对microRNA的靶向降解中的开发和应用。由于它们的高特异性和强效性，SMCs提供了一种空前的化学方法来敲除内源性miRNA，因此应该为生物学发现和治疗发展做出贡献。

更新日期：2020-06-04

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