The effect of pulsed electromagnetic field (PEMF) on bone healing is still uncertain and it has not been established as a standardized treatment. The aim of this systematic review and meta‐analysis is to evaluate the effect of PEMF on bone healing in patients with fracture. We searched CNKI, Wan Fang, VIP, EMbase, PubMed, CENTRAL, Web of Science, Physiotherapy Evidence Database, and Open Grey websites for randomized controlled trials (published before July 2019 in English or Chinese) comparing any form of PEMF to sham. Reference lists were also searched. Related data were extracted by two investigators independently. The bias risk of the articles and the evidence strength of the outcomes were evaluated. Twenty‐two studies were eligible and included in our analysis (n  = 1,468 participants). The pooled results of 14 studies (n  = 1,131 participants) demonstrated that healing rate in PEMF group was 79.7% (443/556), and that in the control group was 64.3% (370/575). PEMF increased healing rate (RR = 1.22; 95% confidence interval [CI] = 1.10–1.35; I ² = 48%) by the Mantel–Haenszel analysis, relieved pain (standardized mean difference (SMD) = −0.49; 95% CI = −0.88 to −0.10; I ² = 60%) by the inverse variance analysis, and accelerated healing time (SMD = −1.01; 95% CI = −2.01 to −0.00; I ² = 90%) by the inverse variance analysis. Moderate quality evidence suggested that PEMF increased healing rate and relieved pain of fracture, and very low‐quality evidence showed that PEMF accelerated healing time. Larger and higher quality randomized controlled trials and pre‐clinical studies of optimal frequency, amplitude, and duration parameters are needed. © 2020 Bioelectromagnetics Society.

中文翻译：

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脉冲电磁场​​对骨愈合的有效性：随机对照试验的系统评价和荟萃分析。

脉冲电磁场​​（PEMF）对骨骼愈合的影响仍不确定，因此尚未建立标准化治疗方法。该系统评价和荟萃分析的目的是评估PEMF对骨折患者骨愈合的影响。我们在CNKI，Wan Fang，VIP，EMbase，PubMed，CENTRAL，Web of Science，物理疗法证据数据库和Open Gray网站上搜索了随机对照试验（于2019年7月之前以英文或中文发布），以比较任何形式的PEMF与假手术。参考名单也进行了搜索。相关数据由两名调查员独立提取。评价文章的偏倚风险和结果的证据强度。第二十二条研究符合，并在我们的分析包括（ñ = 1,468名参与者）。14项研究（n  = 1,131名参与者）的汇总结果表明，PEMF组的治愈率为79.7％（443/556），而对照组的治愈率为64.3％（370/575）。 通过Mantel–Haenszel分析，PEMF可以提高治愈率（RR = 1.22； 95％置信区间[CI] = 1.10–1.35；I ² = 48％），缓解的疼痛（标准平均差（SMD）= −0.49； 95％CI 通过逆方差分析得出= -0.88至-0.10; I ² = 60％）和加速的愈合时间（SMD = -1.01; 95％CI = -2.01至-0.00; I ² = 90％）。中等质量的证据表明PEMF可提高愈合速度并减轻骨折疼痛，非常低质量的证据表明PEMF可以加快愈合时间。需要更大和更高质量的随机对照试验和临床前研究，以研究最佳频率，振幅和持续时间参数。©2020生物电磁学会。