Crimean Congo hemorrhagic fever (CCHF) is a zoonotic viral disease presenting with fever and hemorrhagic manifestations in humans. After several outbreaks of CCHF being reported from Gujarat since 2011 till 2019 and from Rajasthan in 2014 and 2015, the present study reports the CCHF outbreak which was recorded from five human cases in three districts Jodhpur, Jaisalmer, and Sirohi of Rajasthan state since August 2019 till November 2019. A high percent of positivity was recorded in livestock animal samples for the CCHFV IgG antibody. CCHF virus (CCHFV) positive human blood samples and Hyalomma tick pool samples were sequenced using next-generation sequencing method. Two different M segment genotypes, encoding glycoprotein precursor, were identified from tick pools in the study: first from Asian and second from African lineage. The L gene (polymerase) and the S gene (nucleocapsid) clustered in the Asian lineage. The present study illustrates the existence of two different CCHFV lineages being circulating within the Hyalomma tick pools in the Rajasthan state, India. We also observed 3.56% amino acid changes between the death and the survived case of CCHFV in the M gene. This report also sets an alarm to enhance human, tick and livestock surveillance in other districts of Rajasthan and nearby states of India. Biosafety measures, barrier nursing along with the availability of personal protective equipment and ribavirin drug will always be a mainstay in preventing nosocomial infection for proper case management.

克里米亚刚果出血热（CCHF）是一种人畜共患的病毒性疾病，在人类中表现为发烧和出血表现。自2011年至2019年在古吉拉特邦和拉贾斯坦邦分别于2011年和2014年报告了几次CCHF暴发之后，本研究报告了自2019年8月以来在拉贾斯坦邦乔德普尔，斋沙默尔和西罗希三个地区的五例人类病例中记录的CCHF暴发直到2019年11月。在牲畜动物样本中，CCHFV IgG抗体的阳性率很高。CCHF病毒（CCHFV）阳性人类血液样本和透明质酸next池样品使用下一代测序方法进行测序。在研究中从壁虱库中鉴定出两种编码糖蛋白前体的M段基因型：第一种来自亚洲，第二种来自非洲。L基因（聚合酶）和S基因（核衣壳）聚集在亚洲血统中。本研究中示出的两个不同的CCHFV谱系作为内循环的存在璃眼印度拉贾斯坦邦的壁虱池。我们还观察到M基因在CCHFV死亡和幸存病例之间有3.56％的氨基酸变化。该报告还发出警报，以加强拉贾斯坦邦其他地区和印度附近各州的人、,和牲畜监测。生物安全措施，屏障护理以及个人防护设备和利巴韦林药物的供应将始终是预防医院感染以进行适当病例管理的主要手段。