Objective

To compare the effects of meloxicam or carprofen on glomerular filtration rate (GFR), and to evaluate the effect of meloxicam on urinary N-acetyl-β-D-glucosaminidase (NAG) activity, of cats after dental surgery.

Study design

Randomized, blinded, controlled trial.

Animals

A total of 24 mixed breed cats.

Methods

Cats were randomly assigned to one of three groups (n = 8 per group): meloxicam (0.2 mg kg^–1); carprofen (4 mg kg^–1); or saline (2 mL). Acepromazine (0.04 mg kg^–1) and buprenorphine (0.02 mg kg^–1) were administered intramuscularly as preanaesthetic medication. Test drugs were injected subcutaneously at the time of preanaesthetic medication. Anaesthesia was induced with intravenous propofol and maintained with isoflurane in oxygen. Mean arterial blood pressure (MAP), respiratory rate (f_R), heart rate (HR) and haemoglobin oxygen saturation values (SpO₂) were recorded. All cats underwent ultrasonic dental scaling with polishing. Teeth extraction involved mucosal flap creation, removal of alveolar bone and flap closure. Plasma iohexol clearance (ICL), a measure of GFR, was estimated before and 24 hours after anaesthesia induction in all cats. Urinary NAG index was estimated in saline and meloxicam groups at the same time points as GFR. Between-group and -time point differences in GFR and NAG index were compared using mixed model analyses. Data are presented as mean ± standard deviation (p < 0.05).

Results

There was no significant difference in plasma ICL rate (range: from 1.22 ± 0.05 to 1.27 ± 0.04 mL kg minute^–1) between groups or between time points. Urinary NAG index (range: from 1.0 ± 0.19 to 1.36 ± 0.29 Units gram^–1) was not significantly different between meloxicam and saline groups. MAP, HR, f_R and SpO₂ did not differ significantly between groups.

Conclusions and clinical relevance

Meloxicam and carprofen appeared to produce nonsignificant effects on GFR, and meloxicam did not affect the urinary NAG activity, of cats after dental surgery.

中文翻译：

---

非甾体类抗炎药对猫手术后猫肾小球滤过率和尿N-乙酰-β-D-氨基葡萄糖苷酶活性的影响。

目的

为了比较美洛昔康或卡洛芬对猫手术后猫的肾小球滤过率（GFR）的影响，并评估美洛昔康对尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）活性的影响。

学习规划

随机，盲法，对照试验。

动物

共有24只混种猫。

方法

将猫随机分为三组（每组n  = 8）之一：美洛昔康（0.2 mg kg ^–1）；卡洛芬（4 mg kg ^–1）；或生理盐水（2毫升）。肌内注射乙酰苯丙嗪（0.04 mg kg ^–1）和丁丙诺啡（0.02 mg kg ^–1）作为麻醉前药物。在麻醉前用药时皮下注射受试药物。用静脉注射异丙酚诱导麻醉，并用异氟烷在氧气中维持麻醉。平均动脉血压（MAP），呼吸频率（f _R），心率（HR）和血红蛋白氧饱和度值（SpO ₂）进行记录。所有的猫都经过抛光的超声波牙科洗牙。拔牙涉及粘膜皮瓣的产生，牙槽骨的去除和皮瓣的闭合。在所有猫中，在麻醉诱导前和麻醉后24小时估算血浆iohexol清除率（ICL），作为GFR的量度。生理盐水和美洛昔康组在与GFR相同的时间点估算尿NAG指数。使用混合模型分析比较了GFR和NAG指数的组间和时间点差异。数据表示为平均值±标准偏差（p <0.05）。

结果

组之间或时间点之间的血浆ICL率（范围：1.22±0.05至1.27±0.04 mL kg分钟^–1）无显着差异。美洛昔康组和生理盐水组的尿NAG指数（范围从1.0±0.19至1.36±0.29单位克^–1）无显着差异。两组之间的MAP，HR，f _R和SpO ₂没有显着差异。

结论与临床意义

美洛昔康和卡洛芬似乎对牙科手术后的猫无明显影响，而美洛昔康对猫的尿NAG活性没有影响。