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Microwave-promoted one-pot three-component synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by heteropolyanion-based ionic liquids under solvent-free conditions
Tetrahedron ( IF 2.1 ) Pub Date : 2020-06-04 , DOI: 10.1016/j.tet.2020.131312
Yang Yang , Renzhong Fu , Yang Liu , Jing Cai , Xiaojun Zeng

A series of 2,3-dihydroquinazoline-4(1H)-one derivatives have been synthesized via one-pot three-component reaction using isatoic anhydrides, amines and aldehydes (or ketones) catalyzed by heteropolyanion-based ionic liquids under microwave-promoted conditions. The practical protocol was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, solvent-free media and operational simplicity are the main highlights. Furthermore, the catalyst can be recovered and reused without evident loss of reactivity. This method provides a green and much improved protocol over the existing methods.



中文翻译:

杂多阴离子基离子液体在无溶剂条件下微波促进一锅三组分合成2,3-二氢喹唑啉-4(1 H)-酮

在微波促进下,通过杂多阴离子基离子液体催化的等位酸酐,胺和醛(或酮)通过一锅三组分反应合成了一系列2,3-二氢喹唑啉-4(1 H)-one衍生物。条件。发现该实用方案可耐受具有不同官能团的多种底物。中等至极好的产量,无溶剂介质和操作简便是主要亮点。此外,催化剂可以回收和再利用而没有明显的反应性损失。与现有方法相比,该方法提供了绿色且经过改进的协议。

更新日期:2020-06-04
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