In this issue of Cell Stem Cell, Morral et al. (2020) shed new light on the hierarchical organization of cells within colorectal cancer. They show that tumor cells at the apex of this hierarchy reside in particular tumor zones and possess high protein synthesis activity. Interference with their biosynthetic activity results in an irreversible growth arrest of CRC.

中文翻译：

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结肠癌异质性：欢迎来到RiboZone。

在本期的细胞干细胞中，Morral等。（2020）揭示了结直肠癌中细胞的层次结构。他们表明，在该层次的顶点处的肿瘤细胞位于特定的肿瘤区域，并具有较高的蛋白质合成活性。干扰其生物合成活性会导致CRC不可逆转的生长停滞。