The circadian clock temporally organizes cellular physiology throughout the day, allowing daily environmental changes to be anticipated and potentially harmful physiologic processes to be temporally separated. By synchronizing all cells at the tissue level, the circadian clock ensures coherent temporal organismal physiology. Recent advances in our understanding of adult stem cell physiology suggest that aging and perturbations in circadian rhythmicity in stem cells are tightly intertwined. Here we discuss how circadian rhythms regulate and synchronize adult stem cell functions and how alterations in clock function during aging modulate the extrinsic and intrinsic mechanisms that determine adult stem cell homeostasis.

昼夜节律时钟整天在时间上组织细胞生理，从而可以预期每日的环境变化，并在时间上分隔潜在的有害生理过程。通过同步组织水平上的所有细胞，昼夜节律时钟可确保一致的颞部生理机能。我们对成体干细胞生理学的了解的最新进展表明，干细胞中昼夜节律的衰老和扰动紧密地交织在一起。在这里，我们讨论了昼夜节律如何调节和同步成年干细胞的功能，以及衰老过程中时钟功能的变化如何调节决定成年干细胞稳态的外在和内在机制。