Cell ( IF 45.5 ) Pub Date : 2020-06-04 , DOI: 10.1016/j.cell.2020.04.049 Alexandra Vaccaro 1 , Yosef Kaplan Dor 1 , Keishi Nambara 1 , Elizabeth A Pollina 1 , Cindy Lin 1 , Michael E Greenberg 1 , Dragana Rogulja 1
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The view that sleep is essential for survival is supported by the ubiquity of this behavior, the apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep loss can be lethal. The cause of this lethality is unknown. Here we show, using flies and mice, that sleep deprivation leads to accumulation of reactive oxygen species (ROS) and consequent oxidative stress, specifically in the gut. ROS are not just correlates of sleep deprivation but drivers of death: their neutralization prevents oxidative stress and allows flies to have a normal lifespan with little to no sleep. The rescue can be achieved with oral antioxidant compounds or with gut-targeted transgenic expression of antioxidant enzymes. We conclude that death upon severe sleep restriction can be caused by oxidative stress, that the gut is central in this process, and that survival without sleep is possible when ROS accumulation is prevented.
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中文翻译：
睡眠不足会通过肠道中活性氧的积累而导致死亡。
睡眠对于生存至关重要的观点得到了这种行为的普遍性、早期动物中明显存在类似睡眠的状态以及严重的睡眠不足可能是致命的事实的支持。这种致命性的原因尚不清楚。在这里，我们使用苍蝇和小鼠表明，睡眠剥夺会导致活性氧 (ROS) 的积累和随之而来的氧化应激，特别是在肠道中。ROS 不仅与睡眠不足有关，而且是死亡的驱动因素：它们的中和可防止氧化应激，并使苍蝇在几乎没有睡眠的情况下拥有正常的寿命。可以通过口服抗氧化化合物或抗氧化酶的肠道靶向转基因表达来实现拯救。我们得出结论，严重睡眠限制导致的死亡可能是由氧化应激引起的，
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