Pinealectomy can cause a disturbance in emotional status and circadian rhythms of the endocrine and metabolic functions in the body. Endurance training is considered a part of the complex therapy of dysfunctions driven by changes in circadian dynamics of many physiological indicators. In the present study, we aimed to study the effect of endurance training on depressive behavior induced by pinealectomy in rat. We tested the hypothesis that endurance training can have a beneficial impact on depressive behavior induced by pinealectomy in rat via correction of desynchronized circadian rhythms of corticosterone secretion in plasma and brain-derived neurothrophic factor (BDNF) in the hippocampus. The continuous exercise program attenuated depressive responses characterized by the disrupted diurnal rhythm of home-cage motor activity, anhedonia in the sucrose preference test, decreased grooming in the splash test, and despair-like behavior in the forced swimming test of rats with pinealectomy to values resembling those of sham-treated controls. Parallel to the observed positive effect on the emotional status, exercise training diminished total plasma corticosterone levels and corrected its flattened pattern. While the melatonin deficiency did not affect the fluctuations of the BDNF levels, the exercise program induced a considerable and time-dependent increase in its level. These findings suggest that the antidepressant-like effect of endurance training might be mediated via correction of the disturbed circadian rhythm of corticosterone release and enhancement of hippocampal BDNF levels in rats with pinealectomy. Therefore, this alternative mode might have a potential therapeutic application in a subpopulation of people characterized by a melatonin deficiency.

松果体切除术会导致情绪状态和体内内分泌和代谢功能的昼夜节律紊乱。耐力训练被认为是由许多生理指标的昼夜节律动态变化驱动的功能障碍的复杂治疗的一部分。在本研究中，我们旨在研究耐力训练对松果体切除术引起的大鼠抑郁行为的影响。我们测试了以下假设：耐力训练可以通过纠正血浆中皮质酮分泌和海马脑源性神经营养因子 (BDNF) 的不同步昼夜节律，对大鼠松果体切除术诱导的抑郁行为产生有益影响。持续锻炼计划减弱了以家庭笼子运动活动的昼夜节律紊乱为特征的抑郁反应，蔗糖偏好试验中的快感缺乏、飞溅试验中的梳理减少和松果体切除大鼠强迫游泳试验中的绝望样行为，其值与假治疗对照组相似。与观察到的对情绪状态的积极影响平行，运动训练降低了总血浆皮质酮水平并纠正了其扁平模式。虽然褪黑激素缺乏不会影响 BDNF 水平的波动，但锻炼计划会导致其水平显着且依赖于时间的增加。这些发现表明，耐力训练的抗抑郁作用可能是通过纠正松果体切除术大鼠皮质酮释放的昼夜节律紊乱和提高海马 BDNF 水平来介导的。所以，