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The Prangos genus: a comprehensive review on traditional use, phytochemistry, and pharmacological activities
Phytochemistry Reviews ( IF 7.7 ) Pub Date : 2020-06-04 , DOI: 10.1007/s11101-020-09688-3
Javad Mottaghipisheh , Tivadar Kiss , Barbara Tóth , Dezső Csupor

The members of the Prangos genus (Apiaceae) have been widely applied in the Iranian traditional medicine internally and externally for different purposes. The aim of this review is to summarize the ethnomedicinal and food applications of Prangos species and to gather the phytochemical and pharmacological data on this genus. Among the 129 constituents isolated from Prangos species, coumarin derivatives are the main compounds. Several papers report the compositions of essential oils obtained from different plant parts, mostly containing monoterpene and sesquiterpene hydrocarbons. Various pharmacological activities of essential oils, crude extracts or isolated compounds of the Prangos species have been observed, primarily in in vitro experiments. Antioxidant, antimicrobial, cytotoxic and anti-proliferative activities have been the most extensively studied. The efficacy and safety of Prangos plants have not been assessed in animal experiments or clinical trials. Although their furocoumarin content might be a source of adverse effects, toxic effects of Prangos species have not been reported. It can be concluded, that further preclinical and clinical data are necessary to assess the rationale and safety of the medicinal and food use of Prangos species.



中文翻译:

Prangos属:关于传统用途,植物化学和药理活性的全面综述

该成员Prangos属(伞形科)已经在伊朗传统医学为不同的目的广泛应用于内部和外部。这篇综述的目的是总结Prangos物种的民族学和食品应用,并收集该属的植物化学和药理学数据。从Prangos物种中分离出的129种成分中,香豆素衍生物是主要化合物。几篇论文报道了从不同植物部位获得的精油的成分,这些精油主要含有单萜和倍半萜碳氢化合物。精油,粗提取物或分离的的化合物的各种药理活性Prangos主要在体外实验中已经观察到了一些物种。抗氧化剂,抗微生物剂,细胞毒性和抗增殖活性已得到最广泛的研究。尚未在动物实验或临床试验中评估过Prangos植物的功效和安全性。尽管它们的呋喃香豆素含量可能是不良反应的来源,但尚未报道Prangos物种的毒性作用。可以得出结论,进一步的临床前和临床数据对于评估Prangos物种的药用和食品使用的理由和安全性是必要的。

更新日期:2020-06-04
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