Many studies showed that the p300/CBP coactivator is limiting. Here we review three studies that showed how transcription complexes formed on viral cis-regulator elements compete with cellular transcription complexes by sequestrating the p300/CBP coactivator. According to the microcompetition model, this sequestering can cause disease. We use the microcompetition model to explain how a specific type of sequestering, caused by a latent virus that has an active cis-regulatory element in its promoter/enhancer that binds the transcription complex p300/CBP·GABP can cause diseases such as cancer, atherosclerosis, diabetes, and certain autoimmune diseases.

中文翻译：

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隔离限制性 p300/CBP、病毒顺式调节元件和疾病的动力学

许多研究表明 p300/CBP 共激活剂是有限的。在这里，我们回顾了三项研究，这些研究表明在病毒顺式调节因子元件上形成的转录复合物如何通过隔离 p300/CBP 共激活因子与细胞转录复合物竞争。根据微竞争模型，这种隔离会导致疾病。我们使用微竞争模型来解释特定类型的隔离是如何由潜在病毒引起的，该病毒在其启动子/增强子中具有活性顺式调节元件，该元件结合转录复合物 p300/CBP·GABP 会导致癌症、动脉粥样硬化等疾病、糖尿病和某些自身免疫性疾病。