Objectives

To correlate contrast-enhanced ultrasound (CEUS) features with pathological prognostic factors of breast invasive ductal carcinomas (IDCs).

Methods

169 patients who were admitted to our hospital with confirmed IDCs diagnosed between August 2017 and June 2019 were selected. CEUS indicators included the time of contrast agent entered the lesion, the degree of enhancement, the boundary of the lesion, whether there was perfusion defect and nourishing blood vessels, and etc. These parameters correlated with traditional prognostic factors (tumour size, histological grade, axillary lymph node status) and immunohistochemical biomarkers (ER, PR, c-erbB-2, Ki-67, and TOPO-II).

Results

Perfusion defects after enhancement were predictive factors of PR negative expression (r = − 0.318, OR = 0.239) and TOPO-II overexpression (r = 0.284, OR = 3.577). Centripetal enhancement was negatively correlated with ER expression (r = − 0.350, OR = 0.246). The lesions with a larger range after enhancement than the conventional ultrasound had a higher histological grade (r = 0.215). Perfusion defects were positively correlated with lymph node metastasis (r = 0.221) and negatively correlated with the expression of ER and PR (r = − 0.342, r = − 0.318).

Conclusions

Contrast-enhanced ultrasound features of IDCs have a certain correlation with pathological prognostic factors, which is conducive in assessing the prognosis of these patients.

中文翻译：

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乳腺浸润性导管癌中对比增强超声特征与预后因素的相关性。

目标

将对比增强超声 (CEUS) 特征与乳腺浸润性导管癌 (IDC) 的病理预后因素相关联。

方法

选择了2017年8月至2019年6月期间在我院确诊的169例确诊为IDC的患者。CEUS 指标包括造影剂进入病灶的时间、强化程度、病灶边界、是否存在灌注缺损和滋养血管等。这些参数与传统预后因素（肿瘤大小、组织学分级、腋淋巴结状态）和免疫组织化学生物标志物（ER、PR、c-erbB-2、Ki-67 和 TOPO-II）。

结果

增强后的灌注缺陷是 PR 阴性表达 ( r  = − 0.318, OR = 0.239) 和 TOPO-II 过度表达 ( r  = 0.284, OR = 3.577) 的预测因素。向心增强与 ER 表达呈负相关（r  = - 0.350，OR = 0.246）。增强后比常规超声范围更大的病变具有更高的组织学分级（r  = 0.215）。灌注缺损与淋巴结转移呈正相关（r  =0.221），与ER和PR的表达呈负相关（r  =-0.342，r  =-0.318）。

结论

IDCs的超声造影特征与病理预后因素有一定的相关性，有利于评估这些患者的预后。