Abstract

Antibacterial fabrics have attracted wide attention since bacterial infection remains a leading threat to global health due to the abuse of antibiotics and the emergence and spread of drug-resistant pathogens. A novel tert‐butoxycarbonyl (Boc) protected guanidine containing isocyanate group (NCO) (IGUA-Boc) was developed and covalently bonded onto the cotton fabric surface to fabricate excellent antibacterial cotton fabrics with negligible cytotoxicity via dipping-padding-drying process followed by deprotection of Boc group through the acidification process. The guanidine-functionalized cotton fabrics could well retain their mechanical properties, hydrophilicity, moisture permeability, air permeability, softness and whiteness. More importantly, the antibacterial rates of the guanidine-functionalized cotton fabrics against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus were up to 88.5% and 99.9%, respectively even after 50 laundering cycles, which were much larger than that finished with commercial antibacterial agents. Therefore, these guanidine-functionalized cotton fabrics and their finishing method have well potential for applications in surgical equipment, hospitals, hotels and daily necessities.

Graphic abstract

A novel tert‐butoxycarbonyl protected guanidine containing isocyanate group was developed and covalently bonded onto the cotton fabric surface to fabricate excellent antibacterial cotton fabrics without compromising their physicochemical properties and cytocompatibility via dipping-padding-drying followed by deprotection of Boc group

中文翻译：

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胍基功能化棉织物，可实现持久的抗菌活性而又不损害其理化性质和细胞相容性

摘要

抗菌织物已引起广泛关注，因为由于滥用抗生素以及耐药病原体的出现和传播，细菌感染仍然是对全球健康的主要威胁。开发了一种新型的叔丁氧羰基（Boc）保护的含异氰酸酯基团（NCO）的胍（IGUA-Boc），并将其共价键合在棉织物表面上，通过浸涂，浸轧，干燥和脱保护处理，可制造出具有极低细胞毒性的抗菌棉织物Boc基团通过酸化过程。胍官能化的棉织物可以很好地保留其机械性能，亲水性，透湿性，透气性，柔软性和白度。更重要的是，胍基功能化棉织物对革兰氏阴性菌的抗菌率即使经过50个洗涤周期，大肠杆菌和革兰氏阳性金黄色葡萄球菌仍分别高达88.5％和99.9％，这比用商业抗菌剂完成的洗涤过程要大得多。因此，这些胍官能化的棉织物及其整理方法在外科手术设备，医院，旅馆和日用品中具有良好的应用潜力。

图形摘要

开发了一种新型的叔丁氧羰基保护的含异氰酸胍基团，并将其共价键合在棉织物表面上，以制造优异的抗菌棉织物，而不会通过浸入-浸轧-干燥然后脱去Boc基团的保护而损害其理化性质和细胞相容性