Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The senescence arrest prevents the development of cancer, and the SASP can promote tissue repair. Recent data suggest that the prolonged presence of senescent cells, and especially the SASP, could be deleterious, and their beneficial effects early in life can become maladaptive such that they drive aging phenotypes and pathologies late in life. It is therefore important to develop strategies to eliminate senescent cells. There are currently under development or approved several immune cell-based therapies for cancer, which could be redesigned to target senescent cells. This review focuses on this possible use of immune cells and discusses how current cell-based therapies could be used for senescent cell removal.

中文翻译：

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免疫细胞在清除有害衰老细胞中的作用。


细胞衰老是一种本质上不可逆的细胞增殖停滞，与复杂的衰老相关分泌表型（SASP）相结合。衰老停滞可以防止癌症的发展，SASP 可以促进组织修复。最近的数据表明，衰老细胞，尤其是 SASP 的长期存在可能是有害的，它们在生命早期的有益作用可能会变得适应不良，从而导致晚年的衰老表型和病理。因此，制定消除衰老细胞的策略非常重要。目前正在开发或批准了几种基于免疫细胞的癌症疗法，这些疗法可以重新设计以针对衰老细胞。本综述重点关注免疫细胞的这种可能用途，并讨论当前基于细胞的疗法如何用于去除衰老细胞。