Ethics and Systems Thinking in Biochemistry: A CRISPR-Based Activity for Undergraduate Students,Journal of Chemical Education

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Ethics and Systems Thinking in Biochemistry: A CRISPR-Based Activity for Undergraduate Students
Journal of Chemical Education ( IF 2.5 ) Pub Date : 2020-06-02 , DOI: 10.1021/acs.jchemed.0c00095
Laura Rowe ₁

Affiliation

This inquiry-based activity introduces students to the CRISPR method of genetic engineering and recent applications of CRISPR-editing. This activity was implemented in a nonmajors chemistry course for first-year students, during a 1 h 50 min laboratory period. However, the activity could easily be adapted, and it is useful for meeting scientific literacy learning goals of a college chemistry course for majors, an introductory college biochemistry course, or an advanced high school chemistry or biology course. For the activity, students self-selected into small groups and then researched a particular topic concerning CRISPR using a series of questions designed to guide their discovery work. Subtopics included both biochemical and application details of CRISPR, as well as social and ethical considerations concerning the genetic engineering of humans. The activity was designed to introduce students to this rapidly burgeoning biochemical method using a systems-based analysis in which social and ethical considerations are considered along with technical details. Groups prepared a short written and oral summary of their findings, and the instructor facilitated a class discussion on the topic following group oral presentations. Pre- and postactivity survey analysis indicated that students found the activity worthwhile and were able to reflect on the potential broader social and ethical implications of CRISPR-editing due to the research and discussions facilitated by the activity.

中文翻译：

生物化学中的伦理学和系统思维：面向学生的基于CRISPR的活动

这项基于探究的活动向学生介绍了基因工程的CRISPR方法和CRISPR编辑的最新应用。在1小时50分钟的实验室时间内，针对一年级学生在非专业化学课程中实施了此活动。但是，该活动可以轻松地进行调整，对于满足专业化学大学课程，生物化学入门课程或高中化学或生物学课程的科学素养学习目标很有用。为了进行这项活动，学生们按小组自我选择，然后使用一系列旨在指导其发现工作的问题研究了有关CRISPR的特定主题。子主题包括CRISPR的生化和应用细节，以及有关人类基因工程的社会和道德考虑。该活动旨在通过基于系统的分析，向学生介绍这种迅速发展的生化方法，在分析中应考虑社会和道德因素以及技术细节。小组准备了一份简短的书面和口头总结，总结了他们的发现，并且在小组口头介绍之后，讲师促进了对该主题的课堂讨论。活动前和活动后的调查分析表明，由于活动的研究和讨论，学生发现这项活动值得并且能够反思CRISPR编辑的潜在更广泛的社会和伦理意义。小组准备了一份简短的书面和口头总结，总结了他们的发现，并且在小组口头介绍之后，讲师促进了对该主题的课堂讨论。活动前和活动后的调查分析表明，由于活动的研究和讨论，学生发现这项活动值得并且能够反思CRISPR编辑的潜在更广泛的社会和伦理意义。小组准备了一份简短的书面和口头总结，总结了他们的发现，并且在小组口头介绍之后，讲师促进了对该主题的课堂讨论。活动前和活动后的调查分析表明，由于活动的研究和讨论，学生发现这项活动值得并且能够反思CRISPR编辑的潜在更广泛的社会和伦理意义。

更新日期：2020-07-14

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