Background & objectives: The study had two aims. 1) Analysis of research projects done in our institution from 2014-2019 to identify products with a potential for commercialization and 2) To understand the effect of product-development variables on research projects to improve the quality of future commercialization-oriented trials. Methods: 338 clinical trials were grouped into 188 projects under the headings irrigants, diagnostic devices, surgical devices, biomaterials and gels. Trials per project, capital, material costs, labour and the cycle times per trial were calculated. To understand the effect these variables, five hypotheses were generated to test whether greater number of trials, successes, higher capital, more investigators per trial and a longer trial duration will result in a product worthy of commercialization. Results: 22 projects had products with a potential for commercialization. Except labour and cycle time (p>0.05), all variables showed significant differences across all projects. Three products were identified as having potential for actual commercialization. It was observed that greater number of trials (χ2=4.6793; p=0.030528) and successes (χ2=20.8134; p<0.00001) in a project along with a higher capital (χ2=12.2662; p=0.000461) will generate a product worthy of commercialization. Interpretation & conclusions: The results seem to suggest that in trials for commercialization, emphasis must be placed on implementing multiple, well-designed clinical trials on a device or product to successfully identify whether it is commercialization-worthy or not. Due attention must be given to the financial aspects of the projects as deficiencies may result in negative impact on the flow and outcomes of a clinical trial.

中文翻译：

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利用私立牙科学院的学术研究开发商业上可行的产品的成本和策略分析

背景与目标：研究有两个目的。1）对我们机构2014-2019年完成的研究项目进行分析，以识别具有商业化潜力的产品； 2）了解产品开发变量对研究项目的影响，以提高未来面向商业化试验的质量。方法：将338项临床试验分为188个项目，分别为冲洗剂，诊断设备，手术设备，生物材料和凝胶。计算每个项目的试验，资金，材料成本，人工和每个试验的周期时间。为了理解这些变量的影响，生成了五个假设以测试更多的试验，成功，更高的资金，每个试验更多的研究人员以及更长的试验持续时间是否会产生值得商业化的产品。结果：22个项目的产品具有商业化潜力。除了人工和周期时间（p> 0.05）外，所有项目的所有变量均显示出显着差异。确定了三种产品具有实际商业化潜力。可以观察到，在一个项目中进行更多的试验（χ2= 4.6793; p = 0.030528）和成功（χ2= 20.8134; p <0.00001）以及更高的资本（χ2= 12.2662; p = 0.000461）会产生有价值的产品商业化。解释与结论：结果似乎表明，在进行商业化试验时，必须将重点放在对设备或产品进行多次精心设计的临床试验上，以成功确定其是否值得商业化。