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Iterative hard thresholding in genome-wide association studies: Generalized linear models, prior weights, and double sparsity.
GigaScience ( IF 11.8 ) Pub Date : 2020-06-03 , DOI: 10.1093/gigascience/giaa044 Benjamin B Chu 1 , Kevin L Keys 2, 3 , Christopher A German 4 , Hua Zhou 4 , Jin J Zhou 5 , Eric M Sobel 1, 6 , Janet S Sinsheimer 1, 4, 6 , Kenneth Lange 1, 6
GigaScience ( IF 11.8 ) Pub Date : 2020-06-03 , DOI: 10.1093/gigascience/giaa044 Benjamin B Chu 1 , Kevin L Keys 2, 3 , Christopher A German 4 , Hua Zhou 4 , Jin J Zhou 5 , Eric M Sobel 1, 6 , Janet S Sinsheimer 1, 4, 6 , Kenneth Lange 1, 6
Affiliation
Consecutive testing of single nucleotide polymorphisms (SNPs) is usually employed to identify genetic variants associated with complex traits. Ideally one should model all covariates in unison, but most existing analysis methods for genome-wide association studies (GWAS) perform only univariate regression.
中文翻译:
全基因组关联研究中的迭代硬阈值:广义线性模型、先验权重和双稀疏。
单核苷酸多态性 (SNP) 的连续测试通常用于识别与复杂性状相关的遗传变异。理想情况下,应该对所有协变量进行统一建模,但大多数现有的全基因组关联研究 (GWAS) 分析方法仅执行单变量回归。
更新日期:2020-06-03
中文翻译:
全基因组关联研究中的迭代硬阈值:广义线性模型、先验权重和双稀疏。
单核苷酸多态性 (SNP) 的连续测试通常用于识别与复杂性状相关的遗传变异。理想情况下,应该对所有协变量进行统一建模,但大多数现有的全基因组关联研究 (GWAS) 分析方法仅执行单变量回归。