Coronary artery and peripheral artery diseases represent different clinical outcomes of atherosclerosis and despite sharing common risk factors the ultimate reasons determining disease presentation are still unclear. The present study sought to define and compare the serum lipid and apolipoprotein profiles of patients undergoing coronary artery bypass grafting and those treated invasively for symptomatic lower extremity peripheral artery disease. Altogether 218 coronary and 280 peripheral artery disease patients treated between 2013 and 2014 in the Tampere University Hospital, Tampere, Finland, with available lipid measurements within two years prior to the intervention were retrospectively analysed. The Extended Friedewald formula neural network model was used to obtain apolipoprotein and lipoprotein subfraction values. Patients undergoing coronary artery bypass surgery had a clear male predominance (82% versus 53%, p < 0.001), lower median age (69 versus 74 years, p < 0.001) and a lower prevalence of smoking (18% versus 32%, p = 0.001) and pulmonary disease (12% versus 20%, p = 0.023) compared to peripheral artery disease patients. There were some differences in the serum lipid profiles between the study groups in the univariable analyses. When controlling for the statistically significant differences in age, sex, urgency of treatment and comorbidities between the groups in a multivariable logistic regression model, higher serum concentrations of apolipoprotein A-I were significantly and independently associated with coronary artery disease (OR 1.11 for 0.01 g/L increase, p = 0.044). In conclusion, patients undergoing coronary artery bypass grafting appear to have higher apolipoprotein A-I levels when compared to patients treated for peripheral artery disease.

冠状动脉和外周动脉疾病代表了动脉粥样硬化的不同临床结果，尽管存在共同的危险因素，但确定疾病表现的最终原因仍不清楚。本研究试图定义和比较接受冠状动脉旁路移植术的患者和有症状下肢周围动脉疾病的侵入性治疗患者的血脂和载脂蛋白谱。回顾性分析了2013年至2014年之间在芬兰坦佩雷的坦佩雷大学医院接受治疗的218例冠心病患者和280例外周动脉疾病患者，并进行了干预前两年内的可用脂质测量。扩展弗里德瓦尔德公式神经网络模型用于获得载脂蛋白和脂蛋白亚组分值。p  <0.001），较低的中位年龄（69岁对74岁，p  <0.001）和较低的吸烟率（18％对32％，p  = 0.001）和肺部疾病（12％对20％，p  = 0.023）给周围动脉疾病患者。在单变量分析中，研究组之间的血清脂质谱存在一些差异。在多变量Logistic回归模型中控制两组之间的年龄，性别，治疗的紧迫性和合并症之间的统计学显着性差异时，较高的载脂蛋白AI血清浓度显着且独立地与冠心病相关（OR 1.11，0.01 g / L）增加，p = 0.044）。总之，与接受外周动脉疾病治疗的患者相比，接受冠状动脉旁路移植术的患者似乎具有更高的载脂蛋白AI水平。