ABSTRACT

Spinosad and temefos are widely used pesticides for chemical control of dengue vector-borne disease (Aedes aegypti). The aim of this study was to compare the effect of acute exposure (7 days) to spinosad (0.5 mg A.I. L⁻¹) and temefos (10 mg A.I. L⁻¹), concentrations used by the Mexican Ministry of Health, on phagocytic capacity (PC) of mononuclear cells of guppies fish (Poecilia reticulata), as well as to assess PC in fish, at 96 days after exposure to those pesticides. Obtained results indicated that spinosad did not alter PC, while an acute exposure to temefos significantly affected phagocytosis and this parameter was maintained downed even 96 days after the acute exposure, suggesting that the immunotoxic effects of temefos may be chronic.

摘要

Spinosad 和 temefos 是广泛用于化学控制登革热病媒传播疾病（埃及伊蚊）的杀虫剂。本研究的目的是比较墨西哥卫生部使用的浓度（0.5 mg AI L ^-1）和替美磷（10 mg AI L ^-1 ）急性暴露（7天）对吞噬能力的影响(PC) 孔雀鱼 ( Poecilia reticulata ) 的单个核细胞)，以及在接触这些杀虫剂后 96 天评估鱼类中的 PC。获得的结果表明，多杀菌素不会改变 PC，而急性暴露于 temefos 会显着影响吞噬作用，并且该参数甚至在急性暴露后 96 天仍保持下降，这表明 temefos 的免疫毒性作用可能是慢性的。