Dietary plant glucosides are phytochemicals whose bioactivity and bioavailability can be modified by glucoside hydrolase activity of intestinal microbiota through the release of acylglycones. Bifidobacteria are gut commensals whose genomic potential indicates host-adaption as they possess a diverse set of glycosyl hydrolases giving access to a variety of dietary glycans. We hypothesized bifidobacteria with β-glucosidase activity could use plant glucosides as fermentation substrate and tested 115 strains assigned to eight different species and from different hosts for their potential to express β-glucosidases and ability to grow in the presence of esculin, amygdalin, and arbutin. Concurrently, the antibacterial activity of arbutin and its acylglycone hydroquinone was investigated. Beta-glucosidase activity of bifidobacteria was species specific and most prevalent in species occurring in human adults and animal hosts. Utilization and fermentation profiles of plant glucosides differed between strains and might provide a competitive benefit enabling the intestinal use of dietary plant glucosides as energy sources. Bifidobacterial β-glucosidase activity can increase the bioactivity of plant glucosides through the release of acylglycone.

中文翻译：

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双歧杆菌β-葡萄糖苷酶的活性和膳食植物糖苷的发酵是特定物种和特定菌株。

膳食植物糖苷是一种植物化学物质，其生物活性和生物利用度可以通过释放酰基糖苷来改善肠道菌群的糖苷水解酶活性。双歧杆菌是肠道共生体，其基因组潜力表明宿主具有适应性，因为它们拥有多种糖基水解酶，可以接触各种饮食聚糖。我们假设具有β-葡糖苷酶活性的双歧杆菌可以使用植物糖苷作为发酵底物，并测试了分配给八个不同物种和来自不同宿主的115个菌株的表达β-葡糖苷酶的潜力以及在七叶皂苷，苦杏仁苷和熊果苷存在下的生长能力。同时，研究了熊果苷及其酰基糖苷氢醌的抗菌活性。双歧杆菌的β-葡萄糖苷酶活性是物种特异性的，并且在人类成年和动物宿主中发生的物种中最为普遍。菌株之间植物糖苷的利用和发酵特性不同，并且可能提供竞争优势，从而可以在肠道上​​使用膳食植物糖苷作为能源。双歧杆菌的β-葡萄糖苷酶活性可以通过释放酰基糖苷来增加植物苷的生物活性。