Preparation of Oxindoles via Visible‐Light‐Induced Amination/Cyclization of Arylacrylamides with Alkyl Amines,Advanced Synthesis & Catalysis

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Preparation of Oxindoles via Visible‐Light‐Induced Amination/Cyclization of Arylacrylamides with Alkyl Amines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-06-02 , DOI: 10.1002/adsc.202000609
Yu‐Zhao Wang ₁ , Wu‐Jie Lin ₁ , Jian‐Yu Zou ₁ , Wei Yu ₁ , Xue‐Yuan Liu ₁

Affiliation

The cascade amination/cyclization of N‐arylacrylamides with alkyl amines under visible‐light photoredox catalysis is realized via intermediacy of aminium radicals. The aminium radicals are generated by a two‐step sequence which involves N‐chlorination of alkyl amines and subsequent reductive N−Cl cleavage. This method provides a convenient access to aminated oxindoles.

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