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Mice lacking paternal expression of imprinted Grb10 are risk-takers.
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2020-06-02 , DOI: 10.1111/gbb.12679
Claire L Dent 1 , Kira D A Rienecker 1 , Andrew Ward 2 , Jon F Wilkins 3 , Trevor Humby 4 , Anthony R Isles 1
Affiliation  

The imprinted genes Grb10 and Nesp influence impulsive behavior on a delay discounting task in an opposite manner. A recently developed theory suggests that this pattern of behavior may be representative of predicted effects of imprinted genes on tolerance to risk. Here we examine whether mice lacking paternal expression of Grb10 show abnormal behavior across a number of measures indicative of risk‐taking. Although Grb10+/p mice show no difference from wild type (WT) littermates in their willingness to explore a novel environment, their behavior on an explicit test of risk‐taking, namely the Predator Odor Risk‐Taking task, is indicative of an increased willingness to take risks. Follow‐up tests suggest that this risk‐taking is not simply because of a general decrease in fear, or a general increase in motivation for a food reward, but reflects a change in the trade‐off between cost and reward. These data, coupled with previous work on the impulsive behavior of Grb10+/p mice in the delayed reinforcement task, and taken together with our work on mice lacking maternal Nesp, suggest that maternally and paternally expressed imprinted genes oppositely influence risk‐taking behavior as predicted.

中文翻译:

缺乏印迹 Grb10 父系表达的小鼠是冒险者。

印迹基因Grb10Nesp以相反的方式影响延迟折扣任务的冲动行为。最近发展的一种理论表明,这种行为模式可能代表印迹基因对风险耐受性的预测影响。在这里,我们检查了缺乏 Grb10 父系表达的小鼠是否一系列表明冒险行为的指标中表现出异常行为。虽然Grb10 +/p小鼠在探索新环境的意愿方面与野生型 (WT) 同窝仔没有区别,它们在明确的冒险测试(即捕食者气味冒险任务)中的行为表明冒险意愿增加。后续测试表明,这种冒险行为不仅仅是因为恐惧的普遍减少或食物奖励的动机普遍增加,而是反映了成本和回报之间权衡的变化。这些数据,再加上之前关于Grb10 +/p小鼠在延迟强化任务中的冲动行为的研究,以及我们对缺乏母体Nesp小鼠的研究,表明母体和父体表达的印迹基因对冒险行为产生相反的影响,因为预料到的。
更新日期:2020-06-02
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