当前位置: X-MOL 学术Eur. J. Org. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Synthetic Studies of 2,2‐Difluorobicyclo[1.1.1]pentanes (BCP‐F2): The Scope and Limitation of Useful Building Blocks for Medicinal Chemists
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-06-02 , DOI: 10.1002/ejoc.202000679
Xiaoshen Ma 1 , Wilfredo Pinto 2 , Luu N. Pham 1 , David L. Sloman 1 , Yongxin Han 1
Affiliation  

We report the syntheses of a range of synthetically useful building blocks containing the 2,2‐difluorobicyclo[1.1.1]pentane (BCP–F2) fragment. By varying the two functional groups on the bridge‐head positions, these analogs could be applied to drug discovery.
image


中文翻译:

2,2-二氟双环[1.1.1]戊烷(BCP-F2)的合成研究:药物化学家有用的构建基的范围和限制

我们报告了一系列合成有用的组成单元,包括2,2-二氟双环[1.1.1]戊烷(BCP-F 2)片段的合成。通过改变桥头位置上的两个官能团,这些类似物可用于药物发现。
图片
更新日期:2020-08-03
down
wechat
bug