Synthetic Studies of 2,2‐Difluorobicyclo[1.1.1]pentanes (BCP‐F2): The Scope and Limitation of Useful Building Blocks for Medicinal Chemists,European Journal of Organic Chemistry

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Synthetic Studies of 2,2‐Difluorobicyclo[1.1.1]pentanes (BCP‐F2): The Scope and Limitation of Useful Building Blocks for Medicinal Chemists
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-06-02 , DOI: 10.1002/ejoc.202000679
Xiaoshen Ma ₁ , Wilfredo Pinto ₂ , Luu N. Pham ₁ , David L. Sloman ₁ , Yongxin Han ₁

Affiliation

We report the syntheses of a range of synthetically useful building blocks containing the 2,2‐difluorobicyclo[1.1.1]pentane (BCP–F₂) fragment. By varying the two functional groups on the bridge‐head positions, these analogs could be applied to drug discovery.