Ansavaricin J, a New Heterocyclic Ring‐fused Streptovaricin from Gene stvP5‐deleted Mutant of Streptomyces spectabilis CCTCC M2017417,Chemistry & Biodiversity

当前位置： X-MOL 学术 › Chem. Biodivers. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Ansavaricin J, a New Heterocyclic Ring‐fused Streptovaricin from Gene stvP5‐deleted Mutant of Streptomyces spectabilis CCTCC M2017417
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-07-27 , DOI: 10.1002/cbdv.201900713
Yuan-Zhen Liu _{1,

2,

3} , Xu Chen ₃ , Zheng-Yuan Li ₃ , Li-Xia Huang _{1,

2} , Yu-Hui Sun ₃

Affiliation

A new ring-fused streptovaricin analogue, named ansavaricin J ( 1 ), together with the known compound ansavaricin E, were unprecedently isolated from the culture of the genetically modified strains ΔstvP5 and ΔstvP4 which derived from Streptomyces spectabilis CCTCC M2017417, respectively. Their structures were elucidated via comprehensive spectroscopic analyses, including 1D and 2D NMR tests, and HR-ESI-MS data analysis. Notably, 1 and ansavaricin E represent the only two reported examples of heterocyclic ring-fused streptovaricins thus far, however, it only showed insignificant antibacterial activities against methicillin-resitant Staphylococcus aureus .

中文翻译：

Ansavaricin J，一种来自stvP5基因缺失突变体的新型杂环稠合链霉菌素CCTCC M2017417

从分别源自壮观链霉菌 CCTCC M2017417 的转基因菌株 ΔstvP5 和 ΔstvP4 的培养物中前所未有地分离出一种新的环融合链痘素类似物，命名为 ansavaricin J (1)，以及已知的化合物 ansavaricin E。它们的结构是通过综合光谱分析阐明的，包括 1D 和 2D NMR 测试，以及 HR-ESI-MS 数据分析。值得注意的是，1 和 ansavaricin E 是迄今为止报道的仅有的两个杂环稠环链霉素的例子，然而，它仅对耐甲氧西林的金黄色葡萄球菌显示出微不足道的抗菌活性。

更新日期：2020-07-27

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11