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First Ring-Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-06-02 , DOI: 10.1002/cbic.202000336
Friederike Wesemann 1 , Anja Heutling 1 , Paul Wienecke 1 , Andreas Kirschning 1
Affiliation  

Make it larger! A new variant of the chemo‐biosynthetic concept of mutasynthesis using a multiblocked strain of the ansamitocin producer A. pretiosum yielded new macrolactam proansamitocins as well as the first ring‐expanded maytansin macrolactone.
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中文翻译:

由新的突变型变体访问的第一个扩环的美登素内酯。

加大它!化学合成的化学生物合成概念的一个新变体,使用了多联抗寄生虫生产者A. pretiosum的菌株,产生了新的大内酰胺原安他霉素,以及第一个扩环的美登素大内酯。
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更新日期:2020-06-02
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