This in situ/in vivo study aimed to evaluate the effects of erosion on the surface microhardness, substance loss, and surface roughness of CAD/CAM restorative materials and human enamel. This study used a 2-treatment (14 days each) crossover design with 8 healthy volunteers. Each volunteer wore an intraoral appliance containing 3 CAD/CAM restorative material specimens [IPS e.max CAD, Lava Ultimate CAD/CAM Restorative, and a poly (methyl methacrylate) (PMMA) block for CAD/CAM] and 1 human enamel specimen. The specimens were subjected to in vivo erosion cycles by rinsing with 150 ml of cola drink (4 $\times$ 5 min/day) for 14 days. The surface microhardness, substance loss, and surface roughness of the specimens were measured at baseline (T1), day 7 (T2) and day 14 (T3). The data were statistically analyzed using repeated measures ANOVA and Tukey's test (α = 0.05). After erosion, significant increases in substance loss and surface roughness were observed for enamel, though the surface roughness and substance profile of the tested restorative materials remained unchanged. Erosion significantly decreased the surface microhardness of all materials. For IPS e.max and Lava Ultimate, a significantly higher percentage of surface microhardness loss (%SMH_l) was found at T3 than at T2, while no significant difference was found between T2 and T3 for enamel and the PMMA block. In conclusion, CAD/CAM restorative materials showed smaller changes in surface roughness and the surface profile than human enamel after in situ/in vivo erosion. However, CAD/CAM restorative materials and human enamel showed similar changes in surface microhardness after in situ/in vivo erosion.

这项原位/体内研究旨在评估腐蚀对CAD / CAM修复材料和人类牙釉质的表面显微硬度，物质损失和表面粗糙度的影响。这项研究采用了8名健康志愿者进行2次治疗（每次14天）的交叉设计。每位志愿者佩戴的口腔内器具均包含3个CAD / CAM恢复性材料标本[IPS e.max CAD，Lava Ultimate CAD / CAM恢复性和用于CAD / CAM的聚（甲基丙烯酸甲酯）（PMMA）块]和1个人类牙釉质标本。的标本进行体内通过用150毫升的可乐饮料的漂洗蚀除循环（4-$\times$5分钟/天），持续14天。在基线（T1），第7天（T2）和第14天（T3）测量样品的表面显微硬度，物质损失和表面粗糙度。使用重复测量方差分析和Tukey检验（α= 0.05）对数据进行统计分析。腐蚀后，尽管所测试的修复材料的表面粗糙度和物质分布保持不变，但釉质的物质损失和表面粗糙度却显着增加。侵蚀显着降低了所有材料的表面显微硬度。对于IPS e.max和Lava Ultimate，表面显微硬度损失（％SMH _l）在T3处比在T2处发现，而搪瓷和PMMA嵌段在T2和T3之间没有发现显着差异。总之，在原位/体内腐蚀后，CAD / CAM修复材料在表面粗糙度和表面轮廓上的变化比人类瓷釉小。然而，在原位/体内侵蚀后，CAD / CAM修复材料和人类牙釉质在表面显微硬度方面表现出相似的变化。