Glatiramer acetate increases T- and B -regulatory cells and decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) in an animal model of multiple sclerosis,Journal of Neuroimmunology

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Glatiramer acetate increases T- and B -regulatory cells and decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) in an animal model of multiple sclerosis
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.jneuroim.2020.577281
Rina Aharoni ₁ , Raya Eilam ₂ , Nofar Schottlender ₁ , Lihi Radomir ₁ , Sandra Leistner-Segal ₁ , Tali Feferman ₁ , Dana Hirsch ₂ , Michael Sela ₁ , Ruth Arnon ₁

Affiliation

To identify the mechanisms relevant for the therapeutic effect of glatiramer acetate (GA), we studied T- and B- regulatory cells as well as GM-CSF expression in mice recovered from experimental autoimmune encephalomyelitis (EAE). Selective depletion of Tregs reduced but did not eliminate the ability of GA to ameliorate EAE, indicating a role for additional immune-subsets. The prevalence of Bregs in the periphery and the CNS of EAE-mice increased following GA-treatment. Furthermore, GA downregulated the pathological expression of GM-CSF, on both the protein and mRNA levels. These findings corroborate the broad immunomodulatory mechanism of action of GA in EAE/MS.

中文翻译：

醋酸格拉替雷在多发性硬化症动物模型中增加 T 和 B 调节细胞并减少粒细胞-巨噬细胞集落刺激因子 (GM-CSF)

为了确定与醋酸格拉替雷 (GA) 治疗效果相关的机制，我们研究了从实验性自身免疫性脑脊髓炎 (EAE) 恢复的小鼠中的 T 和 B 调节细胞以及 GM-CSF 表达。Tregs 的选择性消耗降低但并未消除 GA 改善 EAE 的能力，表明额外免疫亚组的作用。GA 治疗后，EAE 小鼠外周和 CNS 中 Bregs 的患病率增加。此外，GA 在蛋白质和 mRNA 水平上下调了 GM-CSF 的病理表达。这些发现证实了 GA 在 EAE/MS 中广泛的免疫调节作用机制。

更新日期：2020-08-01

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