In this paper, a semi-analytical investigation was performed to study the effect of the geometrical parameters of insulator-based dielectrophoresis (iDEP) systems for cell free DNA (cfDNA) trapping. For this purpose, first electrical potential and fluid flow fields were calculated by solving the governing equations including Poisson and Navier-stokes equations with appropriate boundary conditions (BCs) and then a Lagrangian approach was utilized to analyze the motion of cfDNA under the most important forces affected on it including Brownian, Drag, electrophoresis and dielectrophoresis (DEP) forces. The effect of the different parameters such as the electrical conductivity of the medium, shape and geometrical parameters of the insulators on the dielectrophoretic behavior of cfDNA was studied and the optimal value of these parameters was presented. Finally, in order to predict the minimum voltage required for cfDNA trapping, artificial neural network (ANN) was utilized and a relation between input and output parameters was introduced.

在本文中，进行了半分析研究，以研究基于绝缘子的介电电泳（iDEP）系统的几何参数对无细胞DNA（cfDNA）捕获的影响。为此，首先通过求解控制方程（包括具有适当边界条件（BCs）的泊松和Navier-stokes方程）来计算电势和流体流场，然后利用拉格朗日方法分析cfDNA在最重要的作用力下的运动。受其影响包括布朗力，阻力，电泳和介电电泳（DEP）力。研究了不同参数（如介质的电导率，绝缘子的形状和几何参数）对cfDNA介电电泳行为的影响，并提出了这些参数的最佳值。