Women are at significantly greater risk of developing Alzheimer's disease and show higher prevalence of autoimmune conditions relative to men. Women's brain health is historically understudied, and little is therefore known about the mechanisms underlying epidemiological sex differences in neurodegenerative diseases, and how female-specific factors may influence women's brain health across the lifespan. In this review, we summarize recent studies on the immunology of pregnancy and menopause, emphasizing that these major immunological and hormonal transition phases may play a critical part in women's brain aging trajectories.

中文翻译：

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了解女性大脑老化：怀孕和更年期的免疫学

与男性相比，女性患阿尔茨海默病的风险要高得多，并且自身免疫性疾病的患病率更高。女性的大脑健康历来研究不足，因此对神经退行性疾病的流行病学性别差异的潜在机制以及女性特定因素如何影响女性一生的大脑健康知之甚少。在这篇综述中，我们总结了最近关于妊娠和更年期免疫学的研究，强调这些主要的免疫和激素过渡阶段可能在女性大脑衰老轨迹中发挥关键作用。