The study examined effectiveness of liposomal form of dextrazide (inhaled or intraperitoneal), free dextrazide (intraperitoneal), and isoniazid (intraperitoneal) in the treatment of BALB/c mice with BCG-induced granulomatosis. The mice were infected with mycobacteria tuberculosis 3 months prior to onset of treatment. The preparations under examinations were administered twice a week over 2 months. The decrease of the number and size of macrophagal granulomas in mice BCG-induced granulomatosis during treatment was determined by the number of living mycobacteria tuberculosis in these granulomas. The most effective treatment was achieved with liposomal form of dextrazide (a conjugate of oxidized dextran with isonicotinic acid hydrazide) . Macrophages with captured mycobacteria tuberculosis, dextrazide, and dextrazide-loaded liposomes can be incorporated into granulomas. The antimycobacterial effect of dextrazide is an important factor preventing the destructive processes in granulomas and organs via a decrease in the prodestructive potential of lysosomes in macrophages realized after their migration from granulomas.

中文翻译：

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肺结核分枝杆菌的位置和各种右旋肼组合物治疗卡介苗诱导的肉芽肿病小鼠的有效性

该研究检查了脂质体形式的右旋肼（吸入或腹腔内）、游离右旋肼（腹腔内）和异烟肼（腹腔内）在治疗 BCG 诱导的肉芽肿病 BALB/c 小鼠中的有效性。小鼠在治疗开始前 3 个月感染结核分枝杆菌。考试中的准备工作在 2 个月内每周进行两次。治疗期间BCG诱导的肉芽肿小鼠巨噬肉芽肿的数量和大小的减少取决于这些肉芽肿中活的结核分枝杆菌的数量。最有效的治疗是使用脂质体形式的右旋糖酐（氧化右旋糖酐与异烟酸酰肼的缀合物）。巨噬细胞与捕获的结核分枝杆菌、右旋糖酐、载有右旋嗪的脂质体可以掺入肉芽肿中。右旋糖酐的抗分枝杆菌作用是防止肉芽肿和器官破坏过程的重要因素，通过降低巨噬细胞中溶酶体从肉芽肿迁移后实现的破坏潜力。