Palladium-catalyzed ortho-selective C–H hydroxylation of carboxybenzyl-protected benzylamines,Organic Chemistry Frontiers

当前位置： X-MOL 学术 › Org. Chem. Front. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Palladium-catalyzed ortho-selective C–H hydroxylation of carboxybenzyl-protected benzylamines
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2020-06-02 , DOI: 10.1039/c9qo01523j
Chenyang Dai _{1,

2,

3,

4,

5} , Yi Han _{1,

2,

3,

4,

5} , Lingling Liu _{1,

2,

3,

4,

5} , Zhi-Bin Huang _{1,

2,

3,

4,

5} , Da-Qing Shi _{1,

2,

3,

4,

5} , Yingsheng Zhao _{1,

2,

3,

4,

5}

Affiliation

A convenient approach to synthesize o-hydroxybenzylamine via Pd-catalyzed hydroxylation of benzylamine with a removable Cbz-amide as the directing group was developed. Various functional groups were well tolerated, leading to various substituted o-hydroxybenzylamines in moderate to good yields.

中文翻译：