Reactive oxygen species (ROS) are major sources of oxidative stress playing prominent roles in the development of several pathologies including cardiovascular and neurodegenerative diseases or cancers. The presence of transition biometal ions, specifically copper and iron, induces ROS formation by catalyzing the reduction of molecular oxygen to superoxide anion (O₂˙⁻), hydrogen peroxide (H₂O₂) and hydroxyl (HO˙) radical. To limit ROS production and their detrimental effects, we report on the synthesis, physicochemical studies and antioxidant assays of an innovative series of synthetic pentapeptides exhibiting a dual direct/indirect mode of action, both as iron(III)-chelators and as radical scavengers. These combined effects lead to a drastic reduction of in vitro reactive oxygen species production up to 95% for the more reactive hydroxyl radical.

中文翻译：

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金属螯合和自由基清除合成五肽都是活性氧生成的有效抑制剂。

活性氧 (ROS) 是氧化应激的主要来源，在包括心血管和神经退行性疾病或癌症在内的多种疾病的发展中发挥着重要作用。过渡生物金属离子，特别是铜和铁的存在，通过催化分子氧还原为超氧阴离子 (O ₂ ˙ ^- )、过氧化氢 (H ₂ O ₂ ) 和羟基 (HO˙) 自由基来诱导 ROS 的形成。为了限制 ROS 的产生及其不利影响，我们报告了一系列创新的合成五肽的合成、物理化学研究和抗氧化分析，这些合成五肽表现出双重直接/间接作用模式，均作为铁（III)-螯合剂和自由基清除剂。这些综合作用导致体外活性氧的产生急剧减少，活性更高的羟基自由基最多可减少 95%。