Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A.,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-06-02 , DOI: 10.1039/d0cc03055d
Ikenna E Ndukwe ₁ , Xiao Wang ₂ , Nelson Y S Lam ₃ , Kristaps Ermanis ₃ , Kelsey L Alexander ₄ , Matthew J Bertin ₅ , Gary E Martin ₆ , Garrett Muir ₇ , Ian Paterson ₃ , Robert Britton ₇ , Jonathan M Goodman ₃ , Eric J N Helfrich ₈ , Jörn Piel ₈ , William H Gerwick ₉ , R Thomas Williamson ₁₀

Affiliation

Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Analytical Research & Development, Merck & Co. Inc, Rahway, NJ, USA.
University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.
Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, USA and Department of Chemistry, University of California, San Diego, CA, USA.
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA.
Department of Chemistry, Seton Hall University, South Orange, NJ, USA.
Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada.
Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland.
Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, USA.
Department of Chemistry & Biochemistry, University of North Carolina Wilmington, Wilmington, NC, USA.

Characterization of the complex molecular scaffold of the marine polyketide natural product phormidolide A represents a challenge that has persisted for nearly two decades. In light of discordant results arising from recent synthetic and biosynthetic reports, a rigorous study of the configuration of phormidolide A was necessary. This report outlines a synergistic effort employing computational and anisotropic NMR investigation, that provided orthogonal confirmation of the reassigned side chain, as well as supporting a further correction of the C7 stereocenter.

中文翻译：

各向异性和计算 NMR 方法的协同作用揭示了 phormidolide A 的可能构型。

海洋聚酮化合物天然产物佛米多内酯 A 的复杂分子支架的表征是一个持续了近二十年的挑战。鉴于最近的合成和生物合成报告得出的不一致结果，有必要对佛米多内酯 A 的构型进行严格研究。该报告概述了采用计算和各向异性 NMR 研究的协同努力，该研究提供了重新分配的侧链的正交确认，并支持 C7 立构中心的进一步校正。

更新日期：2020-07-09

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11