Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply,Organic Process Research & Development

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Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2020-06-02 , DOI: 10.1021/acs.oprd.0c00233
Chris De Savi ₁ , David L Hughes ₂ , Lisbet Kvaerno ₃

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The outbreak of the COVID-19 pandemic has spurred an intense global effort to repurpose existing approved drugs for its treatment. In this review, we highlight the development of seven small-molecule drugs that are currently being assessed in clinical trials for the treatment of COVID-19. Three sections are presented for each drug: (1) history, mechanism of action, and status of clinical trials; (2) scalable synthetic routes and final forms; and (3) outlook for supply should clinical trials show treatment efficacy. A brief overview of diagnostic testing and vaccine development is also presented.

中文翻译：

通过重新利用小分子药物寻求 COVID-19 治疗：作用机制、临床开发、大规模合成和供应前景

COVID-19 大流行的爆发引发了全球的强烈努力，以重新利用现有已批准的药物来治疗该疾病。在这篇综述中，我们重点介绍了七种小分子药物的开发情况，这些药物目前正在治疗 COVID-19 的临床试验中进行评估。每种药物分为三个部分：（1）历史、作用机制和临床试验状态；(2)可扩展的合成路线和最终形式；(3) 如果临床试验显示治疗效果，则供应前景。还简要概述了诊断测试和疫苗开发。

更新日期：2020-06-19

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