We used EEG source analysis to identify which cortical areas were involved in the automatic and controlled processes of inhibitory control on a flanker task and compared the potential efficacy of recombinant-human erythropoietin (rHuEPO) on the performance of Parkinson’s Disease patients. The samples were 18 medicated PD patients (nine of them received rHuEPO in addition to their usual anti-PD medication through random allocation and the other nine patients were on their regular anti-PD medication only) and 9 age and education-matched healthy controls (HCs) who completed the flanker task with simultaneous EEG recordings. N1 and N2 event-related potential (ERP) components were identified and a low resolution tomography (LORETA) inverse solution was employed to localize the neural generators. Reaction times and errors were increased for the incongruent flankers for PD patients compared to controls. EEG source analysis identified an effect of rHuEPO on the lingual gyri for the early N1 component. N2-related sources in middle cingulate and precuneus were associated with the inhibition of automatic responses evoked by incongruent stimuli differentiated PD and HCs. From our results rHuEPO seems to mediate an effect on N1 sources in lingual gyri but not on behavioural performance. N2-related sources in middle cingulate and precuneus were evoked by incongruent stimuli differentiated PD and HCs.

中文翻译：

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侧卫任务引发的事件相关电位源反映了人类重组促红细胞生成素对帕金森氏病患者的差异作用。

我们使用脑电图来源分析来确定哪些皮质区域参与了侧翼任务抑制控制的自动和受控过程，并比较了重组人促红细胞生成素（rHuEPO）对帕金森氏病患者表现的潜在疗效。样本是18名有药物治疗的PD患者（其中9名是通过随机分配的方式在常规抗PD药物之外接受了rHuEPO治疗，另外9例仅接受常规抗PD药物治疗）和9位年龄和教育程度相匹配的健康对照组（ HCs），他们同时完成了侧翼任务并同时录制了EEG。确定了N1和N2事件相关电位（ERP）组件，并采用了低分辨率断层扫描（LORETA）逆解来定位神经发生器。与对照组相比，PD患者不一致的侧腹反应时间和错误增加。脑电图来源分析确定了rHuEPO对早期N1成分对舌状回的影响。N2相关源中扣带和早产与不适当的刺激分化的PD和HCs引起的自动反应的抑制有关。从我们的结果来看，rHuEPO似乎介导了舌回中的N1来源，但没有影响行为表现。刺激性分化PD和HCs不一致引起中扣带和前胎的N2相关来源。N2相关源中扣带和早产与不适当的刺激分化的PD和HCs引起的自动反应的抑制有关。从我们的结果来看，rHuEPO似乎介导了舌回中的N1来源，但没有影响行为表现。刺激性分化PD和HCs不一致引起了中扣带和前胎的N2相关来源。N2相关源中扣带和早产与不适当的刺激分化的PD和HCs引起的自动反应的抑制有关。从我们的结果来看，rHuEPO似乎介导了舌回中的N1来源，但没有影响行为表现。刺激性分化PD和HCs不一致引起中扣带和前胎的N2相关来源。