Toll-like receptors (TLRs) play an important role in the innate immune response to HIV infection. Single nucleotide polymorphism (SNP) in TLR7 (Gln11Leu) gene has been associated with a rapid decline of CD4T cell count. Hence, we assessed the TLR7 (rs179008, Gln11Leu (A/T) and rs179009, IVS2-151 (A/G)) polymorphism in 150 HIV-infected individuals naïve to ART and 158 healthy controls. The genotyping of TLR7 Gln11Leu (A/T) and IVS2-151 (A/G) polymorphisms was done using the PCR-RFLP method. In univariate analysis, none of the genotype and haplotype of TLR7 Gln11Leu (A/T) and IVS2-151 (A/G) polymorphism differed significantly between HIV-infected individuals and healthy controls. The occurrence of TLR7 rs179009AG genotype in the codominant model and rs179009 AG-GG genotype in the dominant model was significantly reduced in HIV-infected individuals as compared to healthy controls (18.0% vs. 29.1%, , ; 26.7% vs. 36.7%, , ). TLR7 rs179009AG genotype was significantly underrepresented in the intermediate HIV disease stage compared with healthy controls (, ). TLR7 rs179009AG genotype expressed higher in tobacco-consuming HIV-infected individuals compared with nonusers (, ). In conclusion, rs179009 AG-GG and AG genotypes were found reduced in HIV-infected individuals as compared to healthy controls; their higher prevalence in health individuals clearly support that they are associated with reduced risk of acquisition of HIV-1 infection.

中文翻译：

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HIV感染者初次接受ART的TLR7多态性（rs179008和rs179009）。

Toll样受体（TLR）在对HIV感染的天然免疫反应中起重要作用。TLR7（Gln11Leu）基因中的单核苷酸多态性（SNP）与CD4T细胞计数的快速下降有关。因此，我们评估了150名未接受ART的HIV感染者和158名健康对照的TLR7（rs179008，Gln11Leu（A / T）和rs179009，IVS2-151（A / G））多态性。使用PCR-RFLP方法对TLR7 Gln11Leu（A / T）和IVS2-151（A / G）多态性进行基因分型。在单变量分析中，HIV感染者与健康对照之间，TLR7 Gln11Leu（A / T）和IVS2-151（A / G）多态性的基因型和单倍型均无显着差异。TLR7的发生 与健康对照组相比，感染艾滋病毒的个体中，显性模型中的rs179009AG基因型和显性模型中的rs179009AG-GG基因型显着降低（分别为18.0％和29.1％， ， ; 26.7％和36.7％，， ）。与健康对照组相比，在中期HIV疾病阶段，TLR7 rs179009AG基因型的代表性明显偏低（， ）。与非使用者相比，在吸烟且感染HIV的个体中，TLR7 rs179009AG基因型表达更高（， ）。结论是，与健康对照相比，在HIV感染个体中发现rs179009 AG-GG和AG基因型减少；他们在健康个体中较高的患病率清楚地证明了他们与减少HIV-1感染的风险有关。