Prostate cancer (PCa) is the second most commonly diagnosed malignant tumor and the fifth leading cause of cancer death in men in the world. The most common types of tumors are adenocarcinomas. Prostate cancer is a slow-growing cancer. The incidence increases with age. Evaluation of proinflammatory factors such as IL-17A, IL-17F, IL-17RA, and IL-17RC expression makes it possible to assess the impact of inflammatory process on progression of PCa. The aim of the study was to retrospectively assess the histological material of PCa divided into few groups using the Gleason score. Studies were carried out on archival tissue material in the form of paraffin blocks of 40 men with PCa after radical prostatectomy. The control group was composed of 10 men with benign prostatic hyperplasia (BPH). The material was obtained by the transurethral resection of the prostate (TURP). Immunohistochemistry was performed on prepared material using specific primary antibodies against IL-17A, IL-17F, IL-17RA, and IL-17RC. Expression of the antibody to be examined using light microscopy and the Remmele-Stegner score (IRS) in cancer staining was then evaluated. Expression of IL-17 RA was not shown in a group of patients with PCa and in the control group. In the group of patients with Gleason score 8 and 9 PCa, the expression of IL-17A was higher compared to that of IL-17F. In addition, in PCa with an increased grade of Gleason scale, a decrease in the expression of the study inflammatory parameters was found. The inflammatory process has an impact on PCa. A study on IL-17 may become a starting point for further research on an attempt to use, for example, immunotherapy in PCa.

中文翻译：

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考虑到与良性前列腺增生相比较的格里森量表的组织学等级，考虑了组织学等级，前列腺癌中IL-17A，IL-17F，IL-17RA和IL-17RC的表达水平：寻找新的治疗选择。

前列腺癌（PCa）是世界上第二大最常被诊断出的恶性肿瘤，并且是导致癌症死亡的第五大主要原因。最常见的肿瘤类型是腺癌。前列腺癌是一种生长缓慢的癌症。发病率随年龄增加。评估促炎因子，例如IL-17A，IL-17F，IL-17RA和IL-17RC的表达，可以评估炎症过程对PCa进程的影响。该研究的目的是回顾性评估使用格里森评分分为几组的PCa的组织学资料。对前列腺癌根治性切除术后40例PCa男性的石蜡块形式的档案组织材料进行了研究。对照组由10名前列腺增生（BPH）男性组成。该材料通过前列腺经尿道切除术（TURP）获得。使用针对IL-17A，IL-17F，IL-17RA和IL-17RC的特异性一抗对制备的材料进行免疫组织化学。然后评估使用光学显微镜检查的抗体的表达和Remmele-Stegner评分（IRS）在癌症染色中的表达。在PCa患者组和对照组中未显示IL-17 RA的表达。在格里森评分为8和9 PCa的患者组中，IL-17A的表达高于IL-17F。此外，在格里森量表评分升高的PCa中，研究炎症参数的表达降低。炎症过程对PCa有影响。对IL-17的研究可能会成为进一步尝试使用的起点，例如，