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Biosensors for Managing the COVID-19 Cytokine Storm: Challenges Ahead.
ACS Sensors ( IF 8.2 ) Pub Date : 2020-06-02 , DOI: 10.1021/acssensors.0c00979 Steven M Russell , Alejandra Alba-Patiño , Enrique Barón , Marcio Borges 1 , Marta Gonzalez-Freire , Roberto de la Rica
ACS Sensors ( IF 8.2 ) Pub Date : 2020-06-02 , DOI: 10.1021/acssensors.0c00979 Steven M Russell , Alejandra Alba-Patiño , Enrique Barón , Marcio Borges 1 , Marta Gonzalez-Freire , Roberto de la Rica
Affiliation
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The global COVID-19 pandemic has oversaturated many intensive care units to the point of collapse, leading to enormous spikes in death counts. Before critical care becomes a necessity, identifying patients who are likely to become critically ill and providing prompt treatment is a strategy to avoid ICU oversaturation. There is a consensus that a hyperinflammatory syndrome or a “cytokine storm” is responsible for poor outcomes in COVID-19. Measuring cytokine levels at the point of care is required in order to better understand this process. In this Perspective, we summarize the main events behind the cytokine storm in COVID-19 as well as current experimental treatments. We advocate for a new biosensor-enabled paradigm to personalize the management of COVID-19 and stratify patients. Biosensor-guided dosing and timing of immunomodulatory therapies could maximize the benefits of these anti-inflammatory treatments while minimizing deleterious effects. Biosensors will also be essential in order to detect complications such as coinfections and sepsis, which are common in immunosuppressed patients. Finally, we propose the ideal features of these biosensors using some prototypes from the recent literature as examples. Multisensors, lateral flow tests, mobile biosensors, and wearable biosensors are seen as key players for precision medicine in COVID-19.
中文翻译：
用于管理 COVID-19 细胞因子风暴的生物传感器：面临的挑战。
全球新冠肺炎 (COVID-19) 大流行已导致许多重症监护病房人满为患，甚至崩溃，导致死亡人数大幅飙升。在重症监护成为必要之前，识别可能病情危重的患者并提供及时治疗是避免 ICU 过度饱和的策略。人们一致认为，过度炎症综合征或“细胞因子风暴”是导致 COVID-19 预后不良的原因。为了更好地了解这一过程，需要在护理点测量细胞因子水平。在本视角中，我们总结了 COVID-19 细胞因子风暴背后的主要事件以及当前的实验治疗方法。我们提倡采用新的生物传感器模式来个性化 COVID-19 的管理并对患者进行分层。生物传感器引导的免疫调节治疗剂量和时机可以最大限度地发挥这些抗炎治疗的益处，同时最大限度地减少有害影响。生物传感器对于检测免疫抑制患者常见的合并感染和败血症等并发症也至关重要。最后，我们使用最近文献中的一些原型作为示例，提出了这些生物传感器的理想特征。多传感器、侧向层析测试、移动生物传感器和可穿戴生物传感器被视为 COVID-19 精准医疗的关键参与者。
更新日期：2020-06-26
中文翻译：
用于管理 COVID-19 细胞因子风暴的生物传感器：面临的挑战。
全球新冠肺炎 (COVID-19) 大流行已导致许多重症监护病房人满为患，甚至崩溃，导致死亡人数大幅飙升。在重症监护成为必要之前，识别可能病情危重的患者并提供及时治疗是避免 ICU 过度饱和的策略。人们一致认为，过度炎症综合征或“细胞因子风暴”是导致 COVID-19 预后不良的原因。为了更好地了解这一过程，需要在护理点测量细胞因子水平。在本视角中，我们总结了 COVID-19 细胞因子风暴背后的主要事件以及当前的实验治疗方法。我们提倡采用新的生物传感器模式来个性化 COVID-19 的管理并对患者进行分层。生物传感器引导的免疫调节治疗剂量和时机可以最大限度地发挥这些抗炎治疗的益处，同时最大限度地减少有害影响。生物传感器对于检测免疫抑制患者常见的合并感染和败血症等并发症也至关重要。最后，我们使用最近文献中的一些原型作为示例，提出了这些生物传感器的理想特征。多传感器、侧向层析测试、移动生物传感器和可穿戴生物传感器被视为 COVID-19 精准医疗的关键参与者。
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