The labyrinth of intricate circuitry makes the central nervous system quite inept to regenerate its functionality after a devastating injury. Apart from targeting the major inhibitory effect of glial scar associated proteoglycans like chondroitin sulfate and the reactive glial cell secreted inflammatory and growth inhibitory molecules, the other major regeneration stalling component that arises after severe CNS injury is myelin and its associated proteinaceous debris comprising myelin-associated glycoprotein (MAG), neurite outgrowth inhibitor protein (NOGO), and oligodendrocyte myelin glycoprotein (OMgp). Various experiments revealed that, upon neutralization of those myelin inhibitors, regeneration could occur satisfactorily. Any therapeutic intervention which can obliterate the myelin-associated axonal growth-inhibitory protein components will be successful in revival and normal restoration of a patient’s life. The sole purpose of this Viewpoint is to address the inhibitory role of these myelin-associated proteins, usually located at the lesion site, and few recent research trends to explore the scope of therapeutically overcoming the regeneration barrier in healing massive CNS injury.

中文翻译：

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髓鞘相关抑制蛋白作为治疗中枢神经系统损伤的治疗靶点。

复杂电路的迷宫使中枢神经系统无能为力，无法在毁灭性的伤害后恢复其功能。除了针对神经胶质疤痕相关蛋白聚糖（如硫酸软骨素）和反应性神经胶质细胞分泌的炎症和生长抑制分子的主要抑制作用外，在严重的中枢神经系统损伤后出现的另一个主要的再生停滞成分是髓磷脂及其包括与髓磷脂相关的蛋白质碎片糖蛋白（MAG），神经突生长抑制蛋白（NOGO）和少突胶质髓磷脂糖蛋白（OMgp）。各种实验表明，在中和那些髓磷脂抑制剂后，再生可以令人满意地发生。任何可以消除髓磷脂相关的轴突生长抑制蛋白成分的治疗性干预都将成功地复兴和正常恢复患者的生命。该观点的唯一目的是解决通常位于病变部位的这些髓磷脂相关蛋白的抑制作用，以及最近的研究趋势来探索在治疗中枢神经系统损伤的治疗中克服再生障碍的范围。