Abstract

This systematic review and meta-analysis aims to systematically review the fatty acid (FA) composition of breast milk in different populations. We systematically searched the Medline via PubMed, Scopus and Clarivate till July 2019. We initially retrieved 433 articles. Having removed duplicates, with initial searching of title and abstracts, 317 papers were excluded and 80 remained. A meta-analysis of 80 cross-sectional, cohort studies, including 8793 subjects, was conducted. Meta-regression analysis indicated that factors including maternal age (p-values of SFA: 0.03, omega-3: 0.01, trans fats:<0.001, total fatty acids: 0.02), year of conducting study (p-values of SFA: <0.001, MUFA: 0.02, omega-6: 0.04,trans fats: 0.04) and sample size (p-values of SFA: 0.03, PUFA: 0.01, omega-6: 0.01, omega-3:<0.001) contributed to the heterogeneity of meta-analysis. This study indicates the large variation of FA content in maternal milk across different populations. Special concern is necessary for both the quality and total amount of fat intake of pregnant and lactating mothers.

摘要

这项系统的回顾和荟萃分析旨在系统地回顾不同人群中母乳中的脂肪酸（FA）组成。直到2019年7月，我们通过PubMed，Scopus和Clarivate系统搜索了Medline。我们最初检索了433篇文章。删除重复项后，通过初步搜索标题和摘要，排除了317篇论文，剩余80篇论文。进行了包括80793名受试者在内的80项横断面队列研究的荟萃分析。荟萃回归分析表明，因素包括产妇年龄（SFA的p值：0.03，omega-3：0.01，反式脂肪：<0.001，总脂肪酸：0.02），研究的年份（SFA的p值：< 0.001，MUFA：0.02，omega-6：0.04，反式脂肪：0.04）和样本量（p-SFA值：0.03，PUFA：0.01，omega-6：0.01，omega-3：<0.001）有助于荟萃分析的异质性。这项研究表明，不同人群的母乳中FA含量差异很大。孕妇和哺乳期母亲的脂肪摄入质量和总量都需要特别关注。