Abstract

Vitamin D improves bone density and latest studies show adherence to Med-Diet as protective on osteoporosis. This observational study aimed at investigating the relationship between 25(OH)D levels and adherence to Med-Diet. Body weight, BMI, WC, glucose, insulin, 25(OH)D, total cholesterol, high- and low-density lipoprotein cholesterol, triglycerides, uric acid, and creatinine serum levels and insulin resistance were determined in 284 overweight/obese subjects not taking medications or supplements. Adherence to Med-Diet was evaluated by using PREDIMED score. High-level of adherence stood out. 25(OH)D was inversely related to BMI, WC, HOMA-IR, serum insulin and triglycerides, while directly to PREDIMED score. Two different regression models confirmed this positive correlation independently of gender and other parameters showing univariate relationship with 25(OH)D. This study argues that a closer adherence to Med-Diet is independently associated with an increase of 25(OH)D suggesting that higher vitamin D levels may contribute to the protective effect of the Med-Diet on osteoporosis.

摘要

维生素D可改善骨骼密度，最新研究表明，坚持服用Med-Diet可预防骨质疏松症。这项观察性研究旨在调查25（OH）D水平与对Med-Diet的依从性之间的关系。在284名体重超重/肥胖的受试者中，确定了体重，BMI，WC，葡萄糖，胰岛素，25（OH）D，总胆固醇，高和低密度脂蛋白胆固醇，甘油三酸酯，尿酸和肌酐的血清水平和胰岛素抵抗。服用药物或补品。使用PREDIMED评分评估对Med-Diet的依从性。高水平的依从性脱颖而出。25（OH）D与BMI，WC，HOMA-IR，血清胰岛素和甘油三酸酯成反比，而与PREDIMED分数成正比。两种不同的回归模型独立于性别和其他与25（OH）D呈单变量关系的参数，证实了这种正相关性。这项研究认为，对Med-Diet的更紧密依从性与25（OH）D的增加独立相关，这表明较高的维生素D水平可能有助于Med-Diet对骨质疏松症的保护作用。