Abstract

Replacement of food rich in saturated fatty acids (SFAs) with unsaturated fatty acids (UFAs) is a well-known dietary strategy to reduce the risk of cardiovascular disease while its impact on postprandial blood lipids is less examined. This study assessed the effects of fatty acids composition on the postprandial triglycerides and cholesterol responses. Seventeen randomised controlled trials were identified and pooled analysis results revealed that consumption of a UFAs-rich or an SFAs-rich breakfast meal did not acutely affect postprandial triglycerides and cholesterol responses. However, subgroup analysis observed that triglycerides incremental area under the curve was lower with an SFAs-rich meal (SMD: −0.36; 95% CI: −0.57, −0.15) over a less than 8 h duration, while was higher (SMD: 0.59; 95% CI: 0.05, 1.23) over a longer postprandial duration. It suggests that the postprandial duration is of importance when evaluating the effects of fatty acids composition on blood lipid responses.

摘要

用不饱和脂肪酸（UFAs）代替富含饱和脂肪酸（SFA）的食物是一种众所周知的饮食策略，可以降低罹患心血管疾病的风险，同时还需要检查其对餐后血脂的影响。这项研究评估了脂肪酸成分对餐后甘油三酸酯和胆固醇反应的影响。确定了17项随机对照试验，汇总的分析结果表明，食用富含UFA或富含SFA的早餐不会严重影响餐后甘油三酸酯和胆固醇的反应。但是，亚组分析发现，富含SFAs的膳食（SMD：-0.36； 95％CI：-0.57，-0.15）在不到8小时的时间内曲线下的甘油三酸酯增量面积较低，而较高（SMD： 0.59; 95％CI：0.05，1.23）。