This study describes the synthesis of an acridone through the directed lithiation of a diarylamine, and elaboration via the 4,5‐dibromoacridone. The bromo substituents are amenable to Suzuki‐Miyaura coupling. Conversion to a 9‐chloro‐4,5‐dibromoacridine, followed by bromine‐lithium exchange, allows the preparation of a 4,5‐bis (phosphino)‐9‐chloroacridine. The 9‐chloro moiety undergoes nucleophilic aromatic substitution by methoxide or an aryloxide. One‐electron reduction of a 9‐(aryloxy)‐4,5‐bis(phosphino)acridine affords a stable radical anion.

中文翻译：

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配位化学的cr啶变体

这项研究描述了通过直接芳基化二芳基胺和通过4,5-二溴ac啶酮的精制合成one啶酮。溴取代基适合Suzuki-Miyaura偶联。转化为9-氯-4,5-二溴ac啶，然后进行溴-锂交换，可以制备4,5-双（膦基）-9-氯ac啶。9-氯部分经历了甲醇或芳氧基的亲核芳族取代。单电子还原9-（芳氧基）-4,5-双（膦基）ac啶可提供稳定的自由基阴离子。