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Two‐State Reactivity: Personal Recounting of its Conception and Future Prospects
Israel Journal of Chemistry ( IF 2.3 ) Pub Date : 2020-03-30 , DOI: 10.1002/ijch.202000002
Sason Shaik 1
Affiliation  

This essay tells the story of the conception of the Two‐State Reactivity (TSR) notion. Since scientific career is part of life's flow, the story blends sub‐stories of scientific colleagues and events. This is also a story of a beguiling paradigm, which has started from a puzzling reactivity of the diatomic oxidant FeO+, has continued to larger oxidants, like the active species of Cytochrome P450 and of nonheme enzymes, and its extension to reductive processes. Finally, the essay discusses prospects of experimental probing of the reactive spin‐state, and of the transition state constitution for these reactions by means of tunneling‐augmented kinetic isotope effects.

中文翻译:

两国反应:概念的个人叙述和未来前景

本文讲述了“两国反应”(TSR)概念的故事。由于科学事业是生活的一部分,因此该故事融合了科学同事和事件的子故事。这也是一个引人入胜的范例的故事,该范例从双原子氧化剂FeO +令人费解的反应性开始,一直延续到更大的氧化剂,例如细胞色素P450和非血红素酶的活性物种,并将其扩展到还原过程。最后,本文讨论了通过隧穿增强的动力学同位素效应对反应性自旋态以及这些反应的过渡态组成进行实验探测的前景。
更新日期:2020-03-30
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